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| Bachelorprojekt - Softwareteknologi | Project No. 0198: Compilation of high-level designs for fabrication of multi-purpose microfluidic biochips |
| Aktuelle | Tidligere |
Microfluidic biochips (also known as lab-on-a-chip) are an alternative to conventional biochemical laboratories, and are revolutionizing biology. We are interested in a type of biochips where the basic building block is a very small valve. By combining these valves, more complex units (see the videos here) such as mixers, switches, multiplexers can be built up and the technology is therefore referred to as microfluidic Very Large Scale Integration (mVLSI).
These biochips are becoming increasingly complex, with thousands of components, but are designed manually, which is extremely labor intensive and error prone. Designers use drawing tools, e.g., AutoCAD, to manually design the chip.
In this project you will continue the work of former bachelor students towards automatic fabrication of Biochips. In this former work an instruction set, so called "G-Code", was developed which drives a micromilling machine [2] to etch biochips to the desired high-level design. Your project will be focused towards the development of a multi-purpose biochip [3]. This will include the extension of the interface, which links the high-level design to the fabrication (G-Code). While basic components such as channels and valves are already integrated, you will extend this library with complex structures such as mixers or control components, which are necessary to build multi-purpose chips. You will be able to optimize and validate your work by fabricating biochips using our own micromilling machine. Note that you don't need to know about the hardware or biochips out front for this project, as its main focus is on programming and algorithms. This project does however provide the opportunity to also work with hardware other than your computer and validate your work through fabricated biochips.
You can choose if you want to write the thesis in Danish or English. We will provide the examples to test your tool. We're building a research group at DTU on this topic, and we're looking for students to be part of this.
[1] Wajid Hassan Minhass, System-Level Modeling and Synthesis Techniques for Flow-Based Microfluidic Very Large Scale Integration Biochips (pdf), DTU PhD thesis, 2012
[2] www.ncbi.nlm.nih.gov/pmc/articles/PMC3927521/
[3] Ahmed M. AminEmail author et al. Software-programmable continuous-flow multi-purpose lab-on-a-chip link.springer.com/article/10.1007/s10404-013-1180-2
Supervisor(s) Jan Madsen
| Sidst opdateret: Nov 18, 2020 af Hans Henrik Løvengreen |