Imaging based agglutination measurement of magnetic micro-particles on a Lab-on-a-Disc platform

Piyathip Wantiya, Robert Burger, Tommy S. AlstrÝm, Marco Donolato, Maria F. Miniotis, Mikkel F. Hansen, Anette G. Wingren, Anja Boisen

AbstractIn this work we present a magnetic micro beads based agglutination assay on a centrifugal microfluidic platform. An imaging based method is used to quantify bead agglutination and measure the concentration of analyte in solution.

Low-cost and fast point-of-care (POC) testing has been of central interest in the last decade, both in the microfluidics research community as well as for industry. Among the large range of microfluidic platforms available (e.g. pressure driven, electroosmotic or capillary driven), the centrifugal platform is one of the most suitable ones for POC testing due to its robust working principle, low complexity and straight-forward separation of cells.

In summary we demonstrate two agglutination based assays on a centrifugal platform which are read out using an imaging based technology. Currently work is focused on optimizing the CRP assay and integrating sample treatment on disc to perform CRP detection in blood.
TypeConference paper [With referee]
ConferenceProceedings of the 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Year2014    pp. 1419-1421
Notehttp://orbit.dtu.dk/en/publications/imaging-based-agglutination-measurement-of-magnetic-microparticles-on-a-labonadisc-platform%287f799a78-f927-486d-a1c7-8ed883ac45a8%29.html
BibTeX data [bibtex]
IMM Group(s)Intelligent Signal Processing


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