Seasonal Changes in Brain Serotonin Transporter Binding in Short Serotonin Transporter Linked Polymorphic Region-Allele Carriers but Not in Long-Allele Homozygotes
|Jan Kalbitzer, David Erritzøe, Klaus K. Holst, Finn Årup Nielsen, Lisbeth Marner, Szabolcs Lehel, Tine Arentzen, Terry L. Jernigan, Gitte Moos Knudsen|
A polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) has been associated with seasonality both in patients with seasonal affective disorder and in the general population.
We used in vivo molecular imaging to measure cerebral serotonin transporter (5-HTT) binding in 57 healthy Scandinavians and related the outcome to season of the year and to the 5-HTTLPR carrier status.
We found that the number of daylight minutes at the time of scanning correlated negatively with 5-HTT binding in the putamen and the caudate, with a similar tendency in the thalamus, whereas this association was not observed for the midbrain. Furthermore, in the putamen, an anatomic region with relatively dense serotonin innervation, we found a significant gene × daylight effect, such that there was a negative correlation between 5-HTT binding and daylight minutes in carriers of the short 5-HTTLPR allele but not in homozygote carriers of the long allele.
Our findings are in line with S-carriers having an increased response in neural circuits involved in emotional processing to stressful environmental stimuli but here demonstrated as a endophenotype with dynamic changes in serotonin reuptake.
|Keywords||Molecular neuroimaging, positron emission tomography|
|Type||Journal paper [With referee]|
|Year||2010 Vol. 67 No. 11 pp. 1033-1039|
|BibTeX data|| [bibtex]|
|IMM Group(s)||Intelligent Signal Processing|
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