Knowledge discovery in neuroinformatics: coordinate-based meta-analytic search of neuroscientific literature and its expansion using semantic keyword extraction

Bartlomiej Wilkowski, Marcin Marek Szewczyk

AbstractThe growing number of increasingly sophisticated functional neuroimaging studies of human brain
activity have changed our view on human brain function. Moreover, it has brought the demand for new
tools and services for integration of research findings, wider exchange of information between laboratories
from the same research area and efficient searching of related articles, reviews and other literature.
By integrating multiple studies in meta-analysis a more complete picture is emerging. Since functional
localization in brain is normally represented in form of stereotaxic coordinates, it can be used directly
in the process of retrieving related literature in a given functional context by the measure of coordinate
distance.
We are developing a BredeQuery plugin for SPM pipeline, which offers a direct link to the Brede
Database. The Brede Database, together with BrainMap database, are two of the very few
databases which provide a coordinate-based search for neuroscientific literature. Nevertheless, those
databases contain relatively small number of publications compared to the frequently updated, big
and comprehensive databases like PubMed. We aim at the integration of such two kinds of databases via
implementation of SKEEPMED (Semantic KEyword Extraction Pipeline for MEdical Documents).
The text bodies of publications retrieved via coordinate-based searching are mapped to a medical ontology
(recently we use Metamap software to obtain mappings to UMLS concepts) thus the main context of
the publication can be obtained. SKEEPMED, a modular pipeline implemented in Python, is able then to
select relevant keywords and construct final PubMed query. Since Metamap software is highly configurable
and uses many parameters (semantic types, sources), we are working now on the metaheuristic approach
which can be used for finding the best Metamap configuration for our application. Furthermore, in the
close future we are planning to test the hybrid approach for keyword extraction (ontological approach
together with statistical/machine learning tools).
During our talk we will present recent results of our research and discuss further work and future
plans concerning above-mentioned projects.
TypeMisc [Presentation]
Year2009    Month June
NoteSeminar talk at the National Institutes of Health
Electronic version(s)[pdf]
BibTeX data [bibtex]
IMM Group(s)Intelligent Signal Processing


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