Static analysis of a Model of the LDL degradation pathway

Henrik Pilegaard, Flemming Nielson, Hanne Riis Nielson

AbstractBioAmbients is a derivative of mobile ambients that has shown promise of
describing interesting features of the behaviour of biological systems.
As for other ambient calculi static program analysis can be used to
compute safe approximations of the behavior of modelled systems. We use
these tools to model and analyse the production of cholesterol in living
cells and show that we are able to pinpoint the difference in behaviour
between models of healthy systems and models of mutated systems giving rise to known diseases.
Keywordsstatic analysis, systems biology, biological pathway, LDL degradation
TypeConference paper [With referee]
ConferenceThird International Workshop on Computational Methods in Systems Biology (CMSB'05)
EditorsGordon Plotkin
Year2005    Month April
PublisherUniversity of Edinburgh
BibTeX data [bibtex]
IMM Group(s)Computer Science & Engineering


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