Mining the posterior cingulate: Segregation between memory and pain components

Finn Årup Nielsen, Daniela Balslev, Lars Kai Hansen

AbstractWe present a general method for automatic meta-analyses in neuroscience and apply it on text data from published functional imaging studies to extract main functions associated with a brain area --- the posterior cingulate cortex. Abstracts from PubMed are downloaded, words extracted and converted to a bag-of-words matrix representation. The combined data is analyzed with hierarchical non-negative matrix factorization. We find that the prominent themes in the PCC corpus are episodic memory retrieval and pain. We further characterize the distribution in PCC of the Talairach coordinates available in some of the articles. This shows a tendency to functional segregation between memory and pain components where memory activations are predominantly in the caudal part and pain in the rostral part of PCC.
Keywordstext mining, neuroimaging, magnetic resonance imaging
TypeJournal paper [With referee]
JournalNeuroImage
Year2005    Month June    Vol. 27    No. 3    pp. 520-532
PublisherElsevier
NoteSubmitted in 2004 July, accepted 2005 April 22. The PDF-file here is the submitted version. It differs a bit compared to the final printed version. Look at the Elsevier publisher's homepage or email fn@imm.dtu.dk for a copy of that version.
Electronic version(s)[pdf]
Publication linkhttp://www.imm.dtu.dk/~fn/Nielsen2003Posterior.html
BibTeX data [bibtex]
IMM Group(s)Intelligent Signal Processing


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