@ARTICLE\{IMM2016-06949, author = "K. B. Fr{\o}hling and T. S. Alstr{\o}m and M. Bagge and M. S. Schmidt and M. N. Schmidt and J. Larsen and M. H. Jakobsen and A. Boisen", title = "Surface Enhanced Raman Spectroscopic Study of {DNA} and {6-}mercapto-1-hexanol Interactions Using Large Area Mapping", year = "2016", month = "aug", keywords = "Bayesin modelling, {SERS,} area mapping, {DNA,} {6-}mercapto-1-hexanol, thiol, gold, peak-fitting", journal = "Vibrational Spectroscopy", volume = "", editor = "", number = "", publisher = "Elsevier", url = "http://www2.compute.dtu.dk/pubdb/pubs/6949-full.html", abstract = "The emergence of {2D} {SERS} substrates with large areas of hot spots has enabled data to be gathered at large scale. This work presents a statistical tool for analysing large amounts of {SERS} data by utilizing a peakfitting model in a specific spectral range. By analysing the distributions of Raman intensities and peak positions it is possible to directly inspect the interplay between {DNA} and {6-}mercapto-1-hexanol on gold covered nanopillars. It is demonstrated that optimised functionalization parameters can be extracted from the Raman spectra directly. Using the peak-fitting approach it is possible to avoid miss-interpretation of intensity histograms, where contamination might contribute with an enhanced background and not a peak." }