@MASTERSTHESIS\{IMM2012-06461, author = "A. E. Clemmensen", title = "Estimation of right ventricular ejection fraction using first-pass {FDG-PET} imaging", year = "2012", school = "Technical University of Denmark, {DTU} Informatics, {E-}mail: reception@imm.dtu.dk", address = "Asmussens Alle, Building 305, {DK-}2800 Kgs. Lyngby, Denmark", type = "", note = "Supervisors: Professor Andreas Kj{\ae}r, University of Copenhagen, Rigshospitalet, Professor Rasmus Larsen, rl@imm.dtu.dk, {DTU} Informatics, Professor Knut Conradsen, kc@imm.dtu.dk, {DTU} Informatics", url = "http://www.imm.dtu.dk/English.aspx", abstract = "The right ventricular ejection fraction (RVEF) is an important diagnostic marker, but its complex shape, placement and contraction pattern makes estimations of its viability challenging. Different modalities is used for estimating {RVEF,} with first-pass radionuclide ventriculography (RNV) as one of the most precise and reliable modalities. Using a gamma camera, the tracer bolus is imaged during the initial passage where it is confined to the right side of the heart. This project investigates the possibility of transferring this first-pass concept to positron emission tomography (PET), which has superior sensitivity and the potential of sparing patient for an extra examination. 13 patients referred to a {FDG-PET} scan at Rigshospitalet were scanned in list-mode during the infusion of {FDG}. After initial estimations of arrival and transit time of the first-pass bolus in the heart, {ECG-}gated reconstructions of {4-}6 second were made. An {ROI} covering the right ventricle was drawn, and from time-activity curves, the {RVEF} was estimated. The developed method significantly underestimates {RVEF,} which is most likely due to imprecise {ROI} drawing. Indications of a correlation between the {RVEF} values by {PET} and cMRI is found, but further improvements of the estimation by {PET} are required before any conclusions can be drawn." }