@CONFERENCE\{IMM2007-05122,
    author       = "H. \'{O}lafsd\'{o}ttir and T. A. Darvann and B. K. Ersb{\o}ll and N. V. Hermann and E. Oubel and R. Larsen and A. F. Frangi and P. Larsen and C. A. Perlyn and G. M. Morriss-Kay and S. Kreiborg",
    title        = "Craniofacial Statistical Deformation Models of Wild-type mice and Crouzon mice",
    year         = "2007",
    month        = "feb",
    booktitle    = "International Symposium on Medical Imaging 2007, San Diego, {CA}",
    volume       = "",
    series       = "",
    editor       = "",
    publisher    = "",
    organization = "",
    address      = "",
    url          = "http://www2.compute.dtu.dk/pubdb/pubs/5122-full.html",
    abstract     = "Crouzon syndrome is characterised by the premature fusion of cranial sutures and synchondroses leading to craniofacial growth disturbances. The gene causing the syndrome was discovered approximately a decade ago and recently the first mouse model of the syndrome was generated. In this study, a set of Micro {CT} scannings of the heads of wild-type (normal) mice and Crouzon mice were investigated. Statistical deformation models were built to assess the anatomical differences between the groups, as well as the within-group anatomical variation. Following the approach by Rueckert et al. we built an atlas using {B-}spline-based nonrigid registration and subsequently, the atlas was nonrigidly registered to the cases being modelled. The parameters of these registrations were then used as input to a {PCA}. Using different sets of
registration parameters, different models were constructed to describe (i) the difference between the two groups in anatomical variation and (ii) the within-group variation. These models confirmed many known traits in the wild-type and Crouzon mouse craniofacial anatomy. Moreover, they showed new traits, not reported before."
}