@CONFERENCE\{IMM2005-03614, author = "M. B. Stegmann", title = "Bi-temporal {3D} Active Appearance Modelling", year = "2005", booktitle = "{IAVP} - Image Analysis in Vivo Pharmachology, Roskilde, Denmark", volume = "", series = "", editor = "", publisher = "", organization = "", address = "", url = "http://www2.compute.dtu.dk/pubdb/pubs/3614-full.html", abstract = "Rapid and unsupervised quantitative analysis is of utmost importance to ensure clinical acceptance of many examinations using cardiac magnetic resonance imaging (MRI). We present a framework that aims at fulfilling these goals for the application of left ventricular ejection fraction estimation in fourdimensional {MRI}. The theoretical foundation of our work is the generative two-dimensional Active Appearance Models by Cootes et al., here extended to bi-temporal, three-dimensional models. Further issues treated include correction of respiratory induced slice displacements, systole detection, and a texture model pruning strategy. Cross-validation carried out on clinical-quality scans of twelve volunteers indicates that ejection fraction and cardiac blood pool volumes can be estimated automatically and rapidly with an accuracy on par with typical inter-observer variability." }