@CONFERENCE\{IMM2005-03593, author = "K. V. Skoglund and M. B. Stegmann and C. Ryberg and H. \'{O}lafsd\'{o}ttir and E. Rostrup", title = "Estimation and Perturbation of the Mid-Sagittal Plane and its Effects on Corpus Callosum Morphometry", year = "2005", month = "may", booktitle = "Proc. International Society of Magnetic Resonance In Medicine - {ISMRM} 2005, Miami, Florida, {USA}", volume = "", series = "", editor = "", publisher = "ISMRM", organization = "", address = "", url = "http://www2.compute.dtu.dk/pubdb/pubs/3593-full.html", abstract = "Brain morphometry is an important tool for detecting and monitoring brain pathologies such as epilepsy, dementia [1,2] and multiple sclerosis [3]. A common method is to delineate some well-defined area of the brain to yield a shape for interor intra-subject studies. One such structure is the corpus callosum (CC), the white-matter nervous tissue bridging the left and right cerebral hemisphere. A multitude of papers (e.g. [2]) report on measurements performed on the two-dimensional cross-section of the {CC} defined by the mid-sagittal plane (MSP) which separates the left hemisphere from the right. Differences in shape due to pathologies are often slight (e.g. [1]). This makes it imperative to define the {MSP} in an accurate and consistent manner. This work investigates the importance of proper {MSP} estimation by measuring relative area changes of the {CC} as a function of plane perturbation angle from an estimated optimal {MSP}." }