@PHDTHESIS\{IMM2004-03126,
    author       = "M. B. Stegmann",
    title        = "Generative Interpretation of Medical Images",
    year         = "2004",
    pages        = "248",
    school       = "Informatics and Mathematical Modelling, Technical University of Denmark, {DTU}",
    address      = "Richard Petersens Plads, Building 321, {DK-}2800 Kgs. Lyngby",
    type         = "",
    note         = "Awarded the Nordic Award for the Best Ph.D. Thesis in Image Analysis and Pattern Recognition in the years 2003-2004 at {SCIA'}05.",
    url          = "http://www2.compute.dtu.dk/pubdb/pubs/3126-full.html",
    abstract     = "This thesis describes, proposes and evaluates methods for automated analysis and quantification of medical images. A common theme is the usage of generative methods, which draw inference from unknown images by synthesising new images having shape, pose and appearance similar to the analysed images. The theoretical framework for fulfilling these goals is based on the class of Active Appearance Models, which has been explored and extended in case studies involving cardiac and brain magnetic resonance images (MRI), and chest radiographs. 

Topics treated include model truncation, model compression using wavelets, handling of non-Gaussian variation by means of cluster analysis, correction of respiratory noise in cardiac {MRI,} and the extensions to multi-slice two-dimensional time-series and bi-temporal three-dimensional models.

The medical applications include automated estimation of: left ventricular ejection fraction from {4D} cardiac cine {MRI,} myocardial perfusion in bolus passage cardiac perfusion {MRI,} corpus callosum shape and area in mid-sagittal brain {MRI,} and finally, lung, heart, clavicle location and cardiothoracic ratio in anterior-posterior chest radiographs.",
    isbn_issn    = "IMM-PHD-2004-127"
}