@TECHREPORT\{IMM2003-02834,
    author       = "J. Schj{\o}dt-Eriksen and J. Clausen",
    title        = "Optimization and Simulation in Drug Development - Review and Analysis",
    year         = "2003",
    keywords     = "Pharmaceutical R\&{D,} Drug Discovery and Development, Modelling and simulation, Clinical Trial Simulation Portfolio optimization",
    number       = "",
    series       = "IMM-Technical report-2003-26",
    institution  = "Informatics and Mathematical Modelling, Technical University of Denmark, {DTU}",
    address      = "Richard Petersens Plads, Building 321, {DK-}2800 Kgs. Lyngby",
    type         = "",
    url          = "http://www2.compute.dtu.dk/pubdb/pubs/2834-full.html",
    abstract     = "We give a review of pharmaceutical R\&D and mathematical simulation and optimization methods used to support decision making within the pharmaceutical development process. 

The complex nature of drug development is pointed out through a description of the various phases of the pharmaceutical development process. A part of the paper is dedicated to the use of simulation techniques to support clinical trials. The paper ends with a section describing portfolio modelling methods in the context of the pharmaceutical industry."
}