Surface Enhanced Raman Spectroscopic Study of DNA and 6-mercapto-1-hexanol Interactions Using Large Area Mapping |
| | Abstract | The emergence of 2D SERS substrates with large areas of hot spots has enabled data to be gathered at large
scale. This work presents a statistical tool for analysing large amounts of SERS data by utilizing a peakfitting
model in a specific spectral range. By analysing the distributions of Raman intensities and peak
positions it is possible to directly inspect the interplay between DNA and 6-mercapto-1-hexanol on gold covered nanopillars. It is demonstrated that optimised functionalization parameters can be extracted from the Raman spectra directly. Using the peak-fitting approach it is possible to avoid miss-interpretation of intensity histograms, where contamination might contribute with an enhanced background and not a peak. | | Keywords | Bayesin modelling, SERS, area mapping, DNA, 6-mercapto-1-hexanol, thiol, gold, peak-fitting | | Type | Journal paper [With referee] | | Journal | Vibrational Spectroscopy | | Year | 2016 Month August | | Publisher | Elsevier | | Electronic version(s) | [pdf] | | BibTeX data | [bibtex] | | IMM Group(s) | Intelligent Signal Processing |
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