Breath gating of cardiac PET using 13N-NH3: An optimization for dynamic analysis | Martin Lyngby Lassen
| | Abstract | In this project a correction of the breath-induced movement of the heart for dynamic PET-scans is investigated. The scans in this project was carried out using 13N-NH3 on two dierent PET/CT scanners: a Siemens Biograph 64 and a Siemens mCT PET/CT scanner, respectively. The dynamic analyses are used in the clinic to obtain information on the perfusion in the heart. From the fi ndings in the perfusion it is possible to estimate whether the patient has a disease or not, and to distinguish dierent diseases. The dynamic analysis is traditionally carried out using a non-gated set-up in which it is impossible to correct for the breath induced movements of the heart. It is estimated that a correction for these motions will improve the dynamic analysis, as the gating might change both the estimated ow values inside a defect, and even change the size and outline of the defect.
In this project the breath-motion was estimated using an affi ne transformation on the obtained images, from which the translation, the rotation, scaling and torsion of the heart is found and corrected for. The method was tried on 6 patients who are known to suffer from different heart defects which alters the perfusion in the heart.
The results from the breath-motion corrected data were compared to a non breath-gated gold standard to validate the effect of the gating protocol. The estimated fl ows were changed for all the patients, when analysed using the breath-gated set-up. The changes in the fl ow were explainable by analyzing the correcting parameters. The results were furthermore analysed by statistical analyses of the measured perfusion values and a blind test of the measured flows. | | Type | Master's thesis [Academic thesis] | | Year | 2012 | | Publisher | Technical University of Denmark, DTU Informatics, E-mail: reception@imm.dtu.dk | | Address | Asmussens Alle, Building 305, DK-2800 Kgs. Lyngby, Denmark | | Series | IMM-M.Sc.-2012-04 | | Note | DTU supervisor: Rasmus Larsen, rl@imm.dtu.dk, DTU Informatics | | Electronic version(s) | [pdf] | | Publication link | http://www.imm.dtu.dk/English.aspx | | BibTeX data | [bibtex] | | IMM Group(s) | Image Analysis & Computer Graphics |
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