Multivariate Analysis of Variance: Finding significant growth in mice with craniofacial dysmorphology caused by the Crouzon mutation

Multivariate Analysis of Variance: Finding significant growth in mice with craniofacial dysmorphology caused by the Crouzon mutation
Signe Strann Thorup, Hildur Olafsdottir, Tron Andre Darvann, Nuno Vibe Hermann, Per Larsen, Rasmus Reinhold Paulsen, Chad. A. Perlyn, Gillian Morriss-Kay, Sven Kreiborg, Rasmus Larsen
Abstract	Crouzon syndrome is characterized by growth disturbances caused by premature fusion of the cranial growth zones. A mouse model with mutation Fgfr2C342Y, equivalent to the most common Crouzon syndrome mutation (henceforth called the Crouzon mouse model), has a phenotype showing many parallels to the human counterpart. Quantifying growth in the Crouzon mouse model could test hypotheses of the relationship between craniosynostosis and dysmorphology, leading to better understanding of the causes of Crouzon syndrome as well as providing knowledge relevant for surgery planning. In the present study we used micro-CT scans of 4-week-old mice (N=5) and 6-week-old mice (N=10) with Crouzon syndrome (Fgfr2 C342Y/+) were compared to control groups of 4-week-old wild-type mice (N=5) and 6-week-old wild-type mice (N=10), respectively.
Type	Conference paper [With referee]
Conference	The Eighth French-Danish Workshop on Spatial Statistics and Image Analysis in Biology : Book of Abstracts
Editors
Year	2010 Month May
Electronic version(s)	[pdf]
BibTeX data	[bibtex]
IMM Group(s)	Image Analysis & Computer Graphics