Craniofacial Statistical Deformation Models of Wild-type mice and Crouzon mice |
| | Abstract | Crouzon syndrome is characterised by the premature fusion of cranial sutures and synchondroses leading to craniofacial growth disturbances. The gene causing the syndrome was discovered approximately a decade ago and recently the first mouse model of the syndrome was generated. In this study, a set of Micro CT scannings of the heads of wild-type (normal) mice and Crouzon mice were investigated. Statistical deformation models were built to assess the anatomical differences between the groups, as well as the within-group anatomical variation. Following the approach by Rueckert et al. we built an atlas using B-spline-based nonrigid registration and subsequently, the atlas was nonrigidly registered to the cases being modelled. The parameters of these registrations were then used as input to a PCA. Using different sets of
registration parameters, different models were constructed to describe (i) the difference between the two groups in anatomical variation and (ii) the within-group variation. These models confirmed many known traits in the wild-type and Crouzon mouse craniofacial anatomy. Moreover, they showed new traits, not reported before. | | Type | Conference paper [With referee] | | Conference | International Symposium on Medical Imaging 2007, San Diego, CA | | Year | 2007 Month February | | Electronic version(s) | [pdf] | | BibTeX data | [bibtex] | | IMM Group(s) | Image Analysis & Computer Graphics |
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