@ARTICLE\{IMM2007-04461,
    author       = "C. Ryberg and E. Rostrup and M. B. Stegmann and F. Barkhof and P. Scheltens and E. C. W. van Straaten and F. Fazekas and R. Schmidt and J. M. Ferro and H. Baezner and T. Erkinjuntti and H. Jokinen and L. Wahlund and J. O’Brien and A. M. Basile and L. Pantoni and D. Inzitari and G. Waldemar",
    title        = "Clinical significance of corpus callosum atrophy in a mixed elderly population",
    year         = "2007",
    keywords     = "Corpus Callosum, Leukoaraiosis, {MRI,} motor function, cognition, Age-Related White Matter Changes, {LADIS,} elderly, cognition.",
    journal      = "Neurobiology of Aging",
    volume       = "",
    editor       = "",
    number       = "",
    publisher    = "",
    url          = "http://www2.compute.dtu.dk/pubdb/pubs/4461-full.html",
    abstract     = "Corpus Callosum (CC) is the main tract connecting the hemispheres, but the clinical significance of {CC} atrophy is poorly understood. The aim of this work was to investigate clinical and functional correlates of {CC} atrophy in subjects with Age-Related White Matter Changes (ARWMC). In 569 elderly subjects with {ARWMC} from the Leukoaraiosis And DISability (LADIS) study, the {CC} was segmented on the normalised mid-sagittal Magnetic Resonance Imaging (MRI) slice and subdivided into five regions. Correlations between the {CC} areas and subjective memory complaints, Mini Mental State Examination (MMSE) score, history of depression, Geriatric Depression Scale (GDS) score, subjective gait difficulty, history of falls, walking speed, and total score on the Short Physical Performance Battery (SPPB) were analyzed. 
Significant correlations between {CC} atrophy and {MMSE,} {SPPB,} and walking speed were identified, and the {CC} areas were smaller in subjects with subjective gait difficulty. The correlations remained significant after correction for {ARWMC} grade. In conclusion, {CC} atrophy was independently associated with impaired global cognitive and motor function in subjects with {ARWMC}."
}