Static analysis of a Model of the LDL degradation pathway |
Henrik Pilegaard, Flemming Nielson, Hanne Riis Nielson
|
| Abstract | BioAmbients is a derivative of mobile ambients that has shown promise of
describing interesting features of the behaviour of biological systems.
As for other ambient calculi static program analysis can be used to
compute safe approximations of the behavior of modelled systems. We use
these tools to model and analyse the production of cholesterol in living
cells and show that we are able to pinpoint the difference in behaviour
between models of healthy systems and models of mutated systems giving rise to known diseases. |
| Keywords | static analysis, systems biology, biological pathway, LDL degradation |
| Type | Conference paper [With referee] |
| Conference | Third International Workshop on Computational Methods in Systems Biology (CMSB'05) |
| Editors | Gordon Plotkin |
| Year | 2005 Month April |
| Publisher | University of Edinburgh |
| Electronic version(s) | [pdf] |
| BibTeX data | [bibtex] |
| IMM Group(s) | Computer Science & Engineering |